Triggering Cell Adhesion, Migration or Shape Change with a Dynamic Surface Coating

Stijn F. M. van Dongen^1,*, Paolo Maiuri², Emmanuelle Marie¹, Christophe Tribet¹, Matthieu Piel^2,*

 There's an APP for that: cell-repellent APP (azido-[polylysine-g-PEG]) is used to create substrates for spatially controlled dynamic cell adhesion. The simple addition of a functional peptide to the culture medium rapidly triggers cell adhesion. This highly accessible yet powerful technique allows diverse applications, demonstrated through tissue motility assays, patterned coculturing and triggered cell shape change